The opportunity to work on Anaphylaxis while at King Pharmaceuticals/Meridian – acquired by Pfizer into the Primare Care Division – brought together a wide range of critical skills I developed since leaving the postdoctoral position at Yale University. Engineering background from Lehigh University, MRI, SPECT and X-ray imaging experience from Carnegie-Mellon University and BMS, animal model expertise from BMS all converged to build the mechanistic foundation of how high energy autoinjection facilitates mitigation of rapid progression of emergent disease state conditions.
I developed preclinical and non-clinical studies to elucidate the mechanism of action of drug delivery and PK/PD profiles using High-Energy Autoinjection. See reference for published patent (High Efficiency Auto-Injector Technology (US20120101475A1))*
The High-Energy Power Pack, actively disrupts tissue, induces oscillatory motion which leads to enhanced dispersion that results in superior drug spread and, thus, faster systemic absorption.
- Axial Oscillatory Motion: The patent describes a fast, dampened, back-and-forth vibration of the needle immediately after it reaches maximum injection depth.
- Tissue Disruption: This needle oscillation occurs during the high-pressure drug expulsion, actively disrupting the injection site tissue.
- Enhanced Dispersion: The combined effect prevents the drug from settling as a simple bolus (tight ball). Instead, it drives the drug out into a wide Dispersion Plume.
This process is engineered to ensure that epinephrine rapidly reaches a large peak dispersion volume of at least 800 mm³, ensuring maximal tissue exposure and a faster uptake into the circulatory system.
High-Energy Autoinjectors enable improved Emergency Care
The High Efficiency Auto-Injector represents a significant advancement in emergency drug delivery. By harnessing the power of a high-energy spring system, it delivers medication in less than half a second and uses the resulting kinetic energy to mechanically enhance tissue dispersion. This dual optimization ensures that epinephrine reaches the circulatory system rapidly, maximizing the patient’s chance of a rapid, positive clinical outcome during anaphylaxis.
© *2025 High Efficiency Auto-Injector Analysis. (Gemini 2.5: Based on US20120101475A1 data)
*Hill RL, Wilmot JG, Belluscio BA, Cleary K, Lindisch D, Tucker R, Wilson E, Shukla RB. Comparison of drug delivery with autoinjector versus manual prefilled syringe and between three different autoinjector devices administered in pig thigh. Med Devices (Auckl). 2016 Aug 2;9:257-66. doi: 10.2147/MDER.S83406. PMID: 27536164; PMCID: PMC4976900. https://pubmed.ncbi.nlm.nih.gov/27536164/